What is CBDa?
CBDa, or cannabidiolic acid, is one of the many compounds found in the cannabis plant. The cannabis plant is rich in a variety of compounds, including cannabinoids, flavonoids, alkaloids, and terpenes. CBDa is categorized as a cannabinoid, along with others such as CBD, THC, CBG, CBGa, THCa, and THCV.
Cannabinoids are unique compounds that interact with the endocannabinoid system (ECS), a critical system in the body that regulates several vital processes, including digestion, hormonal balance, pain relief, inflammation, heart health, muscular function, and mental health. The ECS performs these functions through specialized receptors, known as CB1 and CB2. CB1 receptors are primarily located in the brain and central nervous system, while CB2 receptors are found in the immune system, where they play a crucial role in managing the body’s immune response.
How CBDa works for PTSD
While there are limited research studies specifically examining the direct use of CBDa for PTSD, several papers suggest the potential therapeutic benefits of full-spectrum cannabis products containing CBDa in managing PTSD.
It’s important to note that CBD and CBDa interact with the same receptors and targets in the body. However, CBDa offers a more effective response, interacting more readily with these receptors. Information from Nesas Hemp indicates that CBDa is up to 1,000 times more active than CBD in interacting with receptors, particularly in producing anti-nausea and anti-inflammatory effects. As the original compound produced by the hemp plant, health and wellness experts like Inesa Ponomariovaite, CEO of Nesas Hemp, believes it provides a high level of interaction with the ECS thereby promoting general wellbeing including mental health.
Based on available research, full-spectrum CBDa products may help manage PTSD in the following ways:
1. Modulation of the Endocannabinoid System (ECS):
The endocannabinoid system (ECS) is a crucial neuro-modulatory (regulating or adjusting the activity of the nervous system) network that plays a significant role in neuronal development, synaptic plasticity (the brain’s ability to change and adapt), and maintaining homeostasis in immunity, as well as in regulating various physiological functions such as anxiety, pain, metabolic processes, and bone growth. Although the ECS is not widely recognized in mainstream medicine, numerous researchers have identified its vital role in promoting overall health.
Cannabinoids, particularly the acidic forms like CBDa, are known for their ability to modulate the ECS effectively. Information from a 2008 study showed that CBDa is 100 times more potent in reducing inflammation and pain after binding to ECS receptors. It was also reported to 50,000 and 1,000 times more potent than CBD at reducing anxiety and nausea.
CBDa engage with the ECS more readily, leading to a more potent response. By modulating the ECS, full-spectrum CBDa products can help regulate the body’s response to stress, facilitate fear extinction, modulate emotional responses, promote sleep, reduce neuronal inflammation, protect neurons, enhance mood, alleviate chronic pain, lower the risk of substance dependency, and regulate brain activity that controls anxiety and fear that worsen the symptoms of PTSD.
2. Potential for Reducing Intrusive Memories:
Intrusive memories are unwanted, distressing thoughts or images that repeatedly invade your mind, often without warning. These memories typically involve reliving a traumatic event in vivid detail, which can lead to significant emotional distress. Intrusive memories are a hallmark symptom of conditions like PTSD, and they are often triggered by reminders of the trauma, such as specific sounds, smells, or situations that recall the original event.
Research indicates that cannabinoids, including CBDa, may have a potential role in reducing the frequency and intensity of intrusive memories and flashbacks associated with PTSD. CBDa, like other cannabinoids, interacts with the endocannabinoid system (ECS), which is involved in regulating memory processing, emotional responses, and stress.
In studies examining the effects of full-spectrum cannabis on PTSD symptoms, users reported a notable reduction in several key symptoms. Specifically, there was a 62% reduction in the severity of intrusive memories, a 51% reduction in the severity of flashbacks, a 67% reduction in irritability, and a 57% reduction in anxiety. These findings suggest that full-spectrum cannabis products could offer meaningful relief for individuals suffering from PTSD by helping to mitigate the overwhelming impact of intrusive memories and other related symptoms.
3. Serotonin Modulation:
CBDa (cannabidiolic acid) is believed to have a significant influence on serotonin receptors in the brain, particularly the 5-HT1A receptor. This receptor is a key player in maintaining mood balance and emotional well-being. When the serotonin system is out of balance, it can contribute to feelings of anxiety and depression, both of which are prevalent in individuals with PTSD. Several studies have highlighted the potential of CBDa in this area. For example, a research published in Frontiers in Pharmacology indicates that CBDa may be more effective than CBD in modulating serotonin receptors. The study found that CBDa showed a higher affinity for the 5-HT1A receptor and was more potent in producing anti-anxiety effects compared to CBD. These findings are particularly relevant for PTSD, where anxiety and depression are often severe and persistent.
Conclusion
As a natural solution with minimal side effects, CBDa produces a stronger impact on receptors than CBD, making it a promising option for supporting people with mental health conditions, including PTSD. The only downside to using CBDa is the influx of several fake and low-quality products which can be managed if the CBD industry introduces more regulation.Customers also need to focus on purchasing only lab-verified products from reputable sources.
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